Components of medicinal leech saliva

Hirudin = Inhibits blood coagulation by binding to thrombin

Calin = inhibits blood coagulation by blocking the binding of von Willebrand factor to collagen. Inhibits collagen- mediated platelet aggregation

Destabilase = Monomerizing activity. Dissolves fibrin. Thrombolytic effects

Hirustasin = Inhibits kallikrein, trypsin, chymotrypsin, neutropholic cathepsin G

Bdellins = Anti-inflammatory. Inhibits trypsin, plasmin, acrosin

Hyaluronidase = Increases interstitial viscosity. Antibiotic

Tryptase inhibitor =Inhibits proteolytic enzymes of host mast cells

Eglins = Anti-inflammatory = Inhibit the activity of alpha-chymotrypsin, chymase, substilisin, elastase, cathepsin G