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Saturday, November 17, 2007

Components of medicinal leech saliva

Hirudin = Inhibits blood coagulation by binding to thrombin

Calin
= inhibits blood coagulation by blocking the binding of von Willebrand factor to collagen. Inhibits collagen- mediated platelet aggregation

Destabilase = Monomerizing activity. Dissolves fibrin. Thrombolytic effects

Hirustasin
= Inhibits kallikrein, trypsin, chymotrypsin, neutropholic cathepsin G

Bdellins = Anti-inflammatory. Inhibits trypsin, plasmin, acrosin

Hyaluronidase
= Increases interstitial viscosity. Antibiotic

Tryptase inhibitor =Inhibits proteolytic enzymes of host mast cells

Eglins = Anti-inflammatory = Inhibit the activity of alpha-chymotrypsin, chymase, substilisin, elastase, cathepsin G


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